未明原因多部位出血者血小板聚集功能的研究

Study on Platelet Aggregation of Unknown-Cause Multi-Focal Bleeding

本文报道752例未明原因多部位出血患者,特征为易发乌青块、齿龈出血、鼻出血和/或月经过多、眼底出血等;血小板计数和凝血象无异常,而血小板对ADP、花生四烯酸及血小板激活因子诱导的聚集反应有不同的缺陷者,共238例(31.6％)。患者血小板膜糖蛋白水平正常,因而认为本病是一组继发性血小板聚集功能缺陷症。

By using platelet aggregation technique, we analyzed 752 blood samples from patients with multiple focal bleedings, were characterized by bruising easily, gum-bleeding, epistaxis, retinal hemorrhage and/of menorrhagia. The results of platelet count, coagulation profiles and membranous glycoproteins are quite normal. We found that 238 cases making a defect of platelet aggregation response to ADP, arachidonic acid or platelet activating factor-induced. The causes of platelet aggregation defect and multiple focal bleedings are unknown. We considered that these patients were a group of acquired platelet aggregation defect.