新型血小板聚集功能缺陷症的临床观察

Clinical Observe of a New Variant of Platelet Aggregation Defect

本文报告了43例原因不明的皮肤散在瘀斑和/或牙龈出血、鼻衄、月经过多等,排除了其他可能病因所致的继发性出血性疾病,经凝血象、外周血常规检查、血小板功能检查(指ADP诱导的血小板聚集试验)未见异常,但用抗凝剂刺参酸性粘多糖作血小板聚集诱导测定,发现其中有13例(占30.2％)缺乏聚集反应,符合沈迪代病的表现。同时探讨了本病的特点和可能的致病因素。

This paper presents a group of 43 patients with repeated attack of ecchymosis on extremities and/or menorrhagia, sometimes associated with gum bleeding or epistaxis. Excluding to all secondary haemorrhage disease. Laboratory examination BPC, BT, CT and platelet aggregation induced by ADP were all monoral, But use SJAMP as a new platelet-aggregating agent and found 13 of the 43 cases fail to induce platelet aggregation, the abnormality being 30. 2%. It' s clinica feature is confirm to Shen Dis, Disease Mean while the features and probable contributory factors had been studied.