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EXPRESSION OF THE RETINOIC ACID RECEPTORS(RARs)AND RETINOID X RECEPTOR(RXRs)GENES IN BREAST CANCER

EXPRESSION OF THE RETINOIC ACID RECEPTORS (RARs) AND RETINOID X RECEPTOR (RXRs) GENES IN BREAST CANCER
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摘要 A number of studies have been shown that retiniods can inhibit malignant cell growth including certain breast carcinoma cells. Its inhibitory effort is observed only in ER-positive but not in ER-negative breast cancer cells. We examined retinoic acid receptors (RARs) and retinoids X receptors (RXRs) levels in 6 breast carcinoma cell lines and 18 breast cancer biopsy specimens. We found that RAR-α mRNA level was significantly higher in ER positive cell lines and samples. RAR-γ mRNA was expressed at relatively high levels in majority of tumor samples independent of the ER-status while RAR-β mRNA was expressed at low levels. We also found high RXR-α mRNA levels in all of the tumor samples examined while RXR-γ mRNA could not be detected. Our study suggests a possibility that retinoids inhibit tumor cell growth through RAR-a and RAR-α levels may serve as a potential marker to determine responsiveness of patients to retinoids therapy. A number of studies have been shown that retiniods can inhibit malignant cell growth including certain breast carcinoma cells. Its inhibitory effort is observed only in ER-positive but not in ER-negative breast cancer cells. We examined retinoic acid receptors (RARs) and retinoids X receptors (RXRs) levels in 6 breast carcinoma cell lines and 18 breast cancer biopsy specimens. We found that RAR-α mRNA level was significantly higher in ER positive cell lines and samples. RAR-γ mRNA was expressed at relatively high levels in majority of tumor samples independent of the ER-status while RAR-β mRNA was expressed at low levels. We also found high RXR-α mRNA levels in all of the tumor samples examined while RXR-γ mRNA could not be detected. Our study suggests a possibility that retinoids inhibit tumor cell growth through RAR-a and RAR-α levels may serve as a potential marker to determine responsiveness of patients to retinoids therapy.
出处 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1996年第3期4-8,共5页 中国癌症研究(英文版)
关键词 Breast tumor RARs genes RXRs genes Gene expression. Breast tumor, RARs genes, RXRs genes, Gene expression.
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参考文献9

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