脚癣狐臭宁酊剂抗皮肤病真菌及安全性研究

STUDY ON THE TINCTURE OF ANTITINEA PEDIS AND ANTIBROMHIDOSIS INHIBITING SOME FUNGUS OF DERMALOSES AND IT'S SECURITY

脚癣狐臭宁酊剂抗皮肤病真菌沙保弱氏琼脂平皿法抑菌试验结果表明,对人的脚癣、铜钱癣、鱼鳞癣等皮肤病红色毛发癣菌、石膏样毛发癣菌、石膏样小孢子菌、羊毛状小孢子菌、絮状表皮癣茵五种均有较强的杀灭抑制作用;安全性实验结果,对小鼠LD_(50)为1.807±0.0228mg/kg,可见局部皮肤轻度充血(微发红),未见皮肤及内脏瘤(癌)变,亦未见小鼠右耳廓涂药后干变坏死。

Through the Sabouraud's agar bacteriostasis test, we found that the tincture of antitinea pedis and antibromhidosis has strong inhibition at Trichophyton rubrum, T. gypseum, Microsporum gypseum, M.lanosum, Epidermphyton floccosum which may cause man's dermatoses,tinea pedis,tinea corporis and fish skin. The security test showed LD50 is 1. 807± 0. 0228mg/kg. When applied to a rat skin at LD50 of the tincture, local congestive skin can be found, but not serious. There is no viscera lumorigenesis or dry gangrene after being applied at the right auricle.