大鼠胼胝体内神经肽Y免疫反应阳性纤维的发育

DEVELOPMENT OF NEUROPEPTIDE Y IMMUNOREACTIVE FIBERS IN THE CORPUS CALLOSUM OF THE RAT

本实验用免疫组织化学ＡＢＣ法研究了大鼠胼胝体内神经肽Ｙ免疫反应阳性（ＮＰＹ－ＩＲ）纤维的生后发育。结果发现，许多ＮＰＹ－ＩＲ纤维在大鼠出生时便存在于胼胝体内。ＮＰＹ－ＩＲ胼胝体纤维的密度在生后１周内继续逐渐增高，在第２周内达到最高峰。之后，ＮＰＹ－ＩＲ胼胝体纤维的密度逐渐下降，至第３周末时接近成年时的水平，即仅有少量ＮＰＹ－ＩＲ纤维存在于胼胝体内。这些结果提示在大鼠早期生后发育过程中许多ＮＰＹ－ＩＲ胼胝体纤维是暂时性的，其作用可能与大脑皮质的机能发育有关。

Postnatal development of neuropeptide Y--immunoreactive (NPY--IR) fibers in rat corpuscallosum was investigated by means of immunohistochemistry (ABC method). It was foundthat many NPY--IR callosal fibers had appeared in the corpus callosum of the newborn rat.The density of NPY--IR callosal fibers increased during postnatal week (PNW) 1 and peakedin PNW 2. Thereafter,' the density of NPY--IR callosal fibers decreased, and became close tothe adult level by the end of PNW 3. In the adult, only a few NPY--IR fibers were seen in thecorpus callosum.- These results indicate that many NPY--IR callosal fibers during postnataldevelopment are transient and these transient callosal fibers may play a role in the functionaldevelopment of the cerebral cortex.