急性运动性轴索神经病免疫组织化学研究

THE IMMUNOHISTOCHEMICAL STUDY ON ACUTE MOTOR AXONAL NEUROPATHY (AMAN)

本研究发现，急性运动性轴索神经病（ＡＭＡＮ）的病变部位仅存在于脊神经前根及其远端的周围神经，病灶中ＲＣＡ阳性细胞（巨噬细胞）和ＬＣＡ阳性细胞（淋巴细胞）浸润数量均明显少于经典型格林－巴利综合征（ＧＢＳ）；另外，推测ＡＭＡＮ患者雪旺细胞不表达ＨＬＡ－Ⅱ类抗原，提示ＡＭＡＮ在发病机制方面可能不同于经典型ＧＢＳ。

The inflammatory mononuclear cell infiltration in ventral roots and distal motor fibers ofAMAN was less prominent than classical GBS and absent in dorsal roots. Immunohistochemical studies with monoclonal antibodies identified that the above mentioned mononuclear cells were macrophages (RCA+) and pan lymphocytes (PD,/2B11 +). There was amarked increase of HLA Class Ⅱ antigen expression in classical GBS. It suggested that theexpression of Class Ⅱ antigen might be increased in the myelin forming cells─Schwanncells, but not in AMAN. These findings indicated the pathological variability between classical GBS and AMAN, and this variability may reflect differences in pathogenesis.