硬膜外阻滞行剖宫产对产妇及胎儿TXA_2和PGI_2的影响

Effects of Epidural Anesthesia on Materal and Fetal Plasma ThromboxaneA2 and Prostaeylin levels During Caesaren Section

观察25例硬膜外阻滞行剖宫产的正常产妇及胎儿脐血内TXA_2及PGI_2的变化。发现母体在胎儿娩出及术毕时与麻醉前相比,TXA_2及PGI_2均无统计学的改变(P>0.05),胎儿脐血内含量在母体范围内。表明局麻药利多卡因及丁卡因经硬膜外用药后,对TXA_2和PGI_2的平衡无明显影响,可能是由于硬膜外阻滞有效地抑制手术伤害刺激所致的应激反应。

The plasna thromboxane A2(TXA2) and ProstacyIin(PGI2) levels in health 25 parturient women and their fetuses during coesareon section under epidural anesthesia were measured by radioimmunassay. The results demonstraed that as compared with the preoperative plasma levels of TXA2 and PGI2,there were not significant differenes in the maternal ones after immediate delivery and the end of caesarean section (P> 0.05) and the neonatal ones, witch were the plasma levels in the umbilical vein and artery, didn't alter markedly (P>0. 05). It's suggested that the is no affect to the halane of TXA2 and PGI2 after injecting of Xalocaine and Dicaine to epidural spase. Possibly the epidual anesthesoa can effectively depresse the stress responses to caesarean section