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心力衰竭与急性心肌梗塞患者神经内分泌水平的动态比较

Neuroendocrine Changes Comparison in Congestive Heart Failure with Acute Myocardial Infarction
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摘要 通过测定血浆PRA,AI、ALD、ANP及AVP浓度的变化,研究比较CHF和AMI时神经内分泌水平的动态演变。发现CHF患者神经内分泌水平显著高于AMI患者,随着临床症状改善CHF患者神经内分泌水平逐渐下降,AMI患者各项指标变化不一致,PRA及AI在住院第四天显著高于第一天和第八天的水平,ANP及AVP血浆浓度在发病第一天最高,此后逐渐下降。我们认为神经内分泌兴奋性的升高是CHF发生的主要原因,但在AMI时神经内分泌兴奋性的升高是AMI导致的结果。 A consecutive plasma levels of renin (PRA), angiotensin II (AII), aldosterone (ALD), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) were measured in patients with congestive heart failure (CHF) or acute myocardial infarction (AMI). The results showed that the levels of all of the aforementioned hormones were significantly higher in patients with CHF than AMI. With ameliorative clinical symptoms of heart failure, elevated neuroendocrine levels decreased slowly from admission till day 8. Neuroen-docrine changes in AMI were complex. Plasma PRA and AII concentrations were significantly higher on day 4 than on admission and on day 8. Plasma levels of ANP and AVP were shown to be maximal on admission, followed by a decline. The study suggests that neuroendocrine activity cbntributes to the pathogenesis of congestive heart failure, in contrast, AMI causes neuroendocrine activation.
作者 葛志强 成民
机构地区 [
出处 《解放军医药杂志》 CAS 1996年第4期247-249,共3页 Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词 心力衰竭 急性心肌梗塞 神经内分泌 Neuroendocrine Congestive heart failure Acute myocardial infarction
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