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内皮素对眼的作用

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摘要 内皮素(Endothelin, ET)是一种近年来发现的血管活性多肽,也是迄今所知体内最强的缩血管物质,1988年是由Yanagisawa等从猪主动脉内皮细胞培养液中分离纯化出来。其收缩血管作田强于血管紧张素Ⅱ、加压素和神经肽Y,而且作用持久,并参与机体及眼部许多重要功能的调节,在病理生理方面起着重要的意义。
作者 黄秋闽
机构地区 军区总医院眼科
出处 《解放军医药杂志》 CAS 1996年第5期372-375,共4页 Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
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  • 1Inoue A et al.The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proceedings of the National Academy of Sciences of the United States of America . 1989
  • 2Ye X et al.Peptidergic innervation of the retinal vasculature and optic nerve head. Investigative Ophthalmology . 1990
  • 3Nyborg NCB et al.Endothelin 1 induced contraction of bovine retinal small arteries in reversible and abolished by nitrendipine. Investigative Ophthalmology . 1991
  • 4Takahashi K et al.Production of Endothelin 1 by cultured bovine retinal endothelial cells and presence of endothelin receptors on associated pericytes. Diabetes . 1989
  • 5Crocker DJ et al.Role of the pericyte in wound healing.An ultrastructural study. Exp Mol . 1970
  • 6Hughes AD et al.Human vascular responses to en- ??dothelin-1. Journal of Cardiovascular Pharmacology . 1989
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  • 9Orlidge A et al.Inhibition of capillary endothelial cells growth by pericytes and smooth muscle cells. The Journal of Cell Biology . 1987
  • 10Yanagisawa M et al.A novel Potent Vasoconstrictor peptide produced by Vascular endothelial Cells. Nature . 1988

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