用氢呼气试验方法研究小儿乳糖吸收不良的发生状况

Epidemic investigate of lactose malabsorption in normal Chinese children

188名0～6岁汉族健康儿童在服用18/kg乳糖后,采用氢呼吸试验方法,测定乳糖吸收情况。结果表明4～5岁之间乳糖吸收不良的检出率增加最为显著(P<0.01)。而其他各年龄组间虽有差异,且呈逐年增加的趋势,但无统计学意义(P>0.05)。4～5岁是乳糖吸收不良检出率变化最明显的年龄段。2岁以下儿童,乳糖吸收不良的检出率很低,反映这个时期绝大多数的小儿有足够的乳糖酶消化乳糖。3～5岁是一个重要的变化时期,乳糖吸收不良的发生人数从20％增加到7.0％,说明肠道内乳糖酶逐渐减少。到6岁时检出率接近成人水平,为70％左右。

This study of 188 Chinese Chidren between 0 to 6 years old was designed to determine the prevalence of lactose malabsorption and to understand that Chinese Children absorb and utilize the carbohy-drate from milk and milk products. They are full-blood Han nationalitis and health children. The load of lactose is 1g/kg.The technique of breath hydrogen was used after ingestion loctose. Result indicated that children younger than 2 years have a lower prevalente rate. It was suggsted that in the age groups the lac-tase activity was adequate to absorb lactose. The age between 3 to 5 years is a critical period of change with the lactose malabsorption rate rising abruptly from 20 % to 70 % . After 6 years the incidence of lactose malabsorption reached a steady state very close to the malabsorption rate in Chinese adults, about 70 % .