由3-氨基-2-卤代-2-烯亚胺制备3-卤代喹啉

Preparation of 3 - Haloquinolines from 3 -Amino-2-holo -2 -Alkene Imines

紫外光照射3-氨基-2-卤代-2-烯亚胺生成3-卤代喹啉,该反应对氯代衍生物是定量反应(>95％),溴代和碘代喹啉可以较高产率从反应粗产物中容易地分离出来,由于这一反应温和、简便、干净和快速,我们预期这一反应过程将被广泛应用。

The UV irradiation of 3-amino -2 -halo-2-alkene imines yields 3-haloquinolines. The reaction with chloro derivatives is quantitative (>95%)and brom-and iodoqumoines can be easily isolated in good yields from the reaction crudes.Due to its mildness, simpliaty, cleanness and quickness, we anticipate this procedure should be widely applicable.