摘要
Single step and multi step CARE processes are optimized by computer simulations based on the mathematical model proposed previously. The product of purification factor and recovery yield is used as the objective function for optimizing a single step process. The objective function for the optimization of a multi step process is considered to obtain an anticipated product purity at a maximum recovery yield and a minimum number of CARE inividuals. Pairs of the operating conditions (eluant and affinity recycle flow rates) exist to give the maximums of above objective functions when membrane rejections to ligates and contaminants are equal in value. The optimum affinity recycle flow rate decreases with the increase of membrane rejections and equilibrium binding fractions of ligates. For a multi step process, when contaminants are rejected less than ligate, only one pair of the optimum eluant and affinity recycle flow rates exists.
对单级和多级ＣＡＲＥ过程分别进行了最优化分析．单级过程的优化目标函数（Ｆ１）为ＲＥＣ和ＰＦ的积，而多级过程则将获得一定纯度的目标组分情况下的回收率和ＣＡＲＥ级数之比为优化目标函数Ｆ２．结果表明，当膜对目标和杂质组分的截留率相等时，在一定的洗脱液流速ｒｅ范围内，对于每一个ｒｅ均存在一对应的循环流速ｒｅ，使Ｆ１和Ｆ２最大，并且最大值相等；当ｒｅ一定时，最佳ｒｒ随膜的截留率和亲和载体对目标组分的结合分率的增大而降低．对于多级过程，当膜对杂质的截留小于对目标组分的截留时，只存在一组最佳的操作条件（即ｒｅ和ｒｒ）．
