肾切除前肾蒂间歇性阻断促进留存肾代偿性生长的初步研究

Intermittent Brief Occlusion of Renal Pedical Before Nephrectomy Enhanced Compensatory Renal Hypertrophy

为探讨肾切除前肾蒂间歇性阻断对留存肾代偿性生长的影响,用45只Wistar雄性大白鼠随机分为三组,分别行在肾切除(N组),肾蒂间歇性阻断后左肾切除(P组),肾蒂间隙阻断方法为夹闭肾蒂5分钟,松开5分钟,如此重复5次)及假手术(S组)。以术后14天留存肾(右肾)肾重及肾重/体重比值判断肾代偿性生长程度。结果P组肾切除术后留存肾代偿性生长较N组更为明显。表明肾切除前肾蒂间歇阻断明显促进了留存肾的代偿性生长。其机制还有待进一步研究。

The effects of a brief cycle of renal pedicle occlusion (RPO) before nephrertoroy on compen satory renal hypertrophy had been studied. The RPO was done by repeating 5 min of renal pedicle clapping with 5 min interval for 5 times. Three experimental groups of adult male wistar rats were exposed to either left nephrectomy (N, n -15), RPO before left nephrectomy (P, n = 15) or Sham surgery (S. n =15), and for 2 weeks all animals were sacrificed for investigation. Both the increase mm from the baseline (group S) contralateral kidney wet-weight and the kidney wet-weight bbody-weight rates was more significan in group P than that in group N. The results suggest that intermittent brief occlusion of renal pedicle before pephrec-tomy enhanced contralateral compensatory renal hypertrophy.