摘要
It was demonstrated pathologically that the histological structures of kidneys were impaired after subcutaneous injection of gentamycin for 16 consecutive days in rats. Laboratory parameters showed that serum blood urea nitrogen(BUN) and creatinine (Cr) elevated, while the indices of the erythrogenic line reduced markedly, and erythropoietin (EPO) was not detectable by ELISA. When the rats received recombinant human erythropoietin (rhEPO) for 5 d, the level of EPO in serum went up, and the indices of reticulocyte, red blood cell (RBC),hemoglobin (Hb) and hematocrit (Hct) improved rapidly, of which the response of reticulocyte was most sensitive. The results suggested that the erythrogenic function of the bone marrow in rats was enhanced after the stimulation of rhEPO, and the effect of rhEPO was dose dependent.
ＰｈａｒｍａｃｏｄｙｎａｍｉｃｓｔｕｄｙｏｆｒｅｃｏｍｂｉｎａｎｔｈｕｍａｎｅｒｙｔｈｒｏｐｏｉｅｔｉｎｏｎａｒｅｎａｌａｎｅｍｉａｍｏｄｅｌｉｎｄｕｃｅｄｂｙｇｅｎｔａｍｙｃｉｎｉｎｒａｔｓＣａｏＺｈｉｆａｎｇ（曹之舫）；ＪｉａＬｉｎ（贾林）；Ｊｉ...
