摘要
本文报道8名成年男性健康受试者单剂口服法莫替丁颗粒、片剂药代动力学及相对生物利用度比较。8名受试者接受单剂量(40mg)交叉给药(颗粒剂和片剂)后所得药时曲线符合一室模型。其颗粒剂和片剂的平均药代动力学参数分别为:血浆药物峰浓度:110.29±23.59与112.95±23.36μg/L,药物达峰时间:1.66±0.59与1.97±0.53h,消除半衰期:3.53±0.33与3.18±0.53h,药—时曲线下面积:737.11±147.09与721.42+100.94μg/L·h。其相对生物利用度以片剂为100％,颗粒剂的相对生物利用度为102.96±20.05％。
Pharmacokinetics and relative bioavailability of a single oral dose 40 mg famotidine granula and tablet according to a cross over design were studied in eight normal male volunteers ,The results showed that the pharmacolinetics of oral administration famotidine in the healthy voluneers fitted a one - compartment model. The Cmax in granula and tablet were 110. 29±23. 59 and 112. 95±23. 36μg/L;Tmax were 1. 66±0. 59 and 1. 97±0. 53h;T1/2ke were 3. 53±0. 33 and 3. 18±0. 53h; AUC were 737. 11±147. 09 and 721. 42±100. 94 mg/L. h,respectively. The relative bilavailability of famotidine granula was 102. 96±20. 05%.
出处
《四川生理科学杂志》
1996年第2期11-14,共4页
Sichuan Journal of Physiological Sciences
