摘要
The studies were focused on the mechanisms of liver fibrosis and the methods to assess early stage of liver fibrogenesis. On the basis of their 13 years'studies and recent views on hepatic fibrosis,the authors find:(1) Accumulation of extracellular matrix(ECM) in liver fibrogenesis is the result of the increased mRNA of collagens and other connective tissue components;(2) The process of ECM increase is regulated by cytokines;(3) Consequsence of excess deposition of ECM in liver leads to liver injuries,giving rise to' sinusoidal caparilization',a typical change in fibrotic liver:(4) Assay of the serum components of ECM in patients with chronic liver diseases may be a good test for early diagnosis of liver fibrosis.
ＡｎｅｘｐｅｒｉｍｅｎｔａｌａｎｄｃｌｉｎｉｃａｌｓｔｕｄｙｏｆｌｉｖｅｒｆｉｂｒｏｓｉｓＫｏｎｇＸｉａｎｔａｏ（孔宪涛），ＧａｏＦｅｎｇ（高锋）（ＤｅｐａｒｔｍｅｎｔｏｆＣｌｉｎｉｃａｌＩｍｍｕｎｏｌｏｇｙ，ＣｈａｎｇｚｈｅｎｇＨｏｓｐｉｔａｌ，Ｓ...
