PREPARATION　AND　CHARACTERIZATION　OF　A　NEW　COENZYME　B_（12）　ANALOGUE　CONTAINING　2＇，3＇－　DIDEOXYURIDINE

PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B_(12) ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE

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摘要 Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy Anew kind of coenzyme B12 analogue 2',3' ,5' -trideoxyuridinyl-cobalamin(ddUCbl) wasfirst synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridilne wasfirst transormed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reducdhydroxocobalamin. The new analogue was characterized by UV-yis and1 HNMR spectroscopy

作者 Bao Hua ZHU Hong YAN Lai Bin LUO Ze Hua LIU Hui Lan CHEN(Department of Chemistru,Coordination Chemistry Institute and Coordination Chemistry State Key Laboratory,Nanjing University,Nanjing,210093)

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1996年第6期503-504,共2页 中国化学快报（英文版）

分类号 O62 [理学—有机化学]

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1Hui Lan CHEN,Zheng WU,Lai Bin LUO,Bao Hua ZHU (Deparment of Chemistry, Nanjing University, Nanjing, 210093)Hong YAN,Wen Xia TANG (Coordination Chemisty State key Laboratory, Nanjing, 210093).SYNTHESIS　AND　CHARACTERIZATION　OF　COBINAMIDES　CONTAINING　2′－DEOXYNUCLEOSIDES──A　NEW　KIND　OF　VITAMIN　B_（12）　COENZYME　ANALOGUES[J].Chinese Chemical Letters,1994,5(5):377-378.
2李晓燕,孙宏建,李淑兰,崔学桂,刘德信.两种CO（Ⅱ）希夫碱配合物的合成、表征和氧合反应热力学[J].无机化学学报,1994,10(3):311-316. 被引量：9
3韩德艳,陈慧兰,缪强,俞马宏,倪浩,唐雯霞.Study of Coenzyme B_(12) Model Compounds——CNDO/2 Calculation of C_2H_5Co (SB) and RCo (salen) L Complexes[J].Chinese Science Bulletin,1994,39(12):1007-1010.
4高德,郑国栋,高赛,俞汝勤.Study on the Electrosynthesis of Coenzyme B_12 Model Compound by Spectroelectrochemistry[J].Chinese Science Bulletin,1994,39(20):1692-1696.
5XIA, Chi-Zhong,ZHOU, Pei-Wen,DING, Jing-Fan The Institute of Molecular Science, Department of Chemistry,Shanxi University, Taiyuan, 030006.Tetrahydrofolate coenzyme models I·Synthesis of l-methyl-2-phenyl-3-aryl imidazoliniumiodide and benzylildyne(phenyl-substitutef one carbon unit)transfer reactions[J].Chinese Journal of Chemistry,1990,8(4):333-339.
6Hua Jian Xu,Xiao Lan Xu,Yao Fu,Yi Si Feng.Photocatalytic oxidation of primary and secondary benzyl alcohol catalyzed by two coenzyme NAD^+ models[J].Chinese Chemical Letters,2007,18(12):1471-1475. 被引量：2
7YAN, Hong CHEN, Hui-Lan SUN, Hong-Zhe XIE, De-Ping TANG, Wen-XiaDepartment of Chemistry and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, Jiangsu 210008, China.Preparation and spectroscopic properties of 2',5'-dideoxynucleosidylcobalamins[J].Chinese Journal of Chemistry,1994,12(1):33-42.
8谢昆,崔毅,刘有成,傅尧.Catalytic Hydrogenation of α,β-Epoxyketones to β-Hydroxyketones with Two Sulfinyl Analogues of Coenzyme NADH Models[J].Chinese Journal of Chemistry,2007,25(6):839-842.
9鲁云,程津培.Structure, reactivity and mechanism: A comparison of reactivities of the two NAD(P)H models, BNAH and Hantzsch ester[J].Chinese Science Bulletin,1996,41(22):1881-1885.
10AN IMPROVED METHOD TO SYNTHESIZE VITAMIN B_(12) COENZYME ANALOGUES CONTAINING 2′-DEOXYNUCLEOSIDE[J].Chinese Chemical Letters,1992,3(4):245-246.

Chinese Chemical Letters

1996年第6期

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PREPARATION　AND　CHARACTERIZATION　OF　A　NEW　COENZYME　B_（12）　ANALOGUE　CONTAINING　2＇，3＇－　DIDEOXYURIDINE

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PREPARATION　AND　CHARACTERIZATION　OF　A　NEW　COENZYME　B_（12）　ANALOGUE　CONTAINING　2＇，3＇－　DIDEOXYURIDINE