Gate-related receptor hypothesis for sodium-channel blocker antiarrhythmic agents

Sodium-channel blocker is an important class of drugs(Class Ⅰ) used in antiarrhythmictherapy. Its antiarrhythmic effects are mainly due to its capability of blocking cardiac sodiumchannels. Several hypotheses have been offered to explain the mechanisms of action of so-dium-channel blocker, in which the modulated receptor hypothesis (MRH) and guarded re-