Association of lamin A/C with chromosomes in the mitosis of mouse thymus T lymphocytes

The nuclear lamina is a meshwork of intermediate filament-like fibrils situated immediately subjacent to the inner membrane of the nuclear envelope. Together with other proteinaceous elements such as the nuclear pore complex, the lamina forms part of the karyoskeleton, or structural framework of the nucleus. The lamina is thought to play a role in anchoring the nuclear envelope, and/or providing attachment sites for interphase chromatin. Mammalian somatic cells commonly contain three major lamins: A, B and C.