“先心1号汤”治疗小儿先天性心脏房、室间隔缺损的疗效观察

Observation on therapeutic efficacy of “xian xin” decoction (No.1,)in treatment of infant congenital atrial septum defect and ventricular septum defect

目的：探讨中药“先心１号汤”治疗小儿单纯性先天性房、室间隔缺损的疗效。方法：将小儿单纯性先天性房、室间隔缺损患儿随机分为２组。治疗组１３３例中男６６例，女６７例；年龄６个月～１０岁（平均４．３岁）；房间隔缺损（房缺）７５例，室间隔缺损（室缺）５８例。对照组１０５例中男４９例，女５６例；年龄４个月～９岁（平均４．１岁）；房缺６１例，室缺４４例。２组患儿年龄，房、室间隔缺损分型均具可比性。治疗组用“先心１号汤”治疗；对照组不用药，观察缺损自然闭合情况。结果：治疗组患儿服药２个疗程后房缺痊愈５４例（４０．６％），好转１５例（１１．３％）；室缺痊愈４０例（３０．１％），好转１３例（９．８％），总有效率９１．７％。对照组房缺痊愈４例（３．８％），好转６例（５．７％）；室缺痊愈５例（４．８％），好转４例（３．８％），总有效率１８．１％。２组疗效比较，治疗组疗效显著优于对照组，差异显著（Ｐ＜０．０１）。结论：“先心１号汤”治疗小儿单纯性先天性房、室间隔缺损疗效肯定，安全可靠，无毒副作用，值得临床推广。确切机制尚待探讨。

Objective:To explore the therapeutic efficacy of “xian xin” decoction (No.1) in treatment of infant simple congenital atrial septum defect (ASD) and ventricular septum defect (VSD).Methods:Simple congenital ASD and VSD infant patients were divided randomly into 2 groups:treatment group (n=133) and control group (n=105).In the treatment group,66 cases were male and 67 cases were female;the age was from 6 months to 10 years (mean age:43 years old);75 cases were ASD and 58 cases were VSD.In the control group,49 cases were male and 56 cases were female;the age was from 4 months to 9 years (mean age:41 years old);61 cases were ASD and 44 cases were VSD.The ages and the types of ASD and VSD between 2 groups were possessed of comparable.The treatment group was treated with “xian xin” decoction (No.1) but not in control group,and to observe the natural close condition.Results:In the treatment group,54 cases (406%) of ASD were cured,15 cases(113%) were improved;40 cases (301%) of VSD were cured,13 cases (98%) were improved,the total effective rate was 917%.In the control group,4 cases (38%) of ASD were cured,6 cases (57%) were improved;5 cases (48%) of VSD were cured,4 cases (38%) were improved,the total effective rate was 181%.The treatment group was superior obviously to control group,there was obvious difference of therapeutic efficacy between 2 groups (P<001).Conclusions:“Xian xin” decoction (No.1) is a Chinese herb,which is effectiveness,safe and no sideeffect for treating infant simple congenital ASD and VSD.So it is valuable to spread and to investigate the exact mechanism.