联用天保宁与消心痛治疗心绞痛临床疗效观察

Clinical observation on therapeutic efficacy of taponin combined use of isosorbide dinitrate treating angina pectoris

目的：探讨联用天保宁与消心痛治疗心绞痛的疗效。方法：将１５５例冠状动脉粥样硬化性心脏病（冠心病）心绞痛患者随机分为３组，天保宁组５０例（Ａ组），消心痛组５０例（Ｂ组），联用天保宁与消心痛组５５例（Ｃ组）。Ａ组口服天保宁２片，每日３次；Ｂ组口服消心痛１０ｍｇ，每日３次；Ｃ组口服天保宁２片，消心痛１０ｍｇ，每日各３次，服药３周为１个疗程。结果：治疗１个疗程后Ａ、Ｂ、Ｃ３组临床症状改善的总有效率依次为７２．０％、７０．０％和９０．９％（Ｐ＜０．０２５和Ｐ＜０．０１）。心电图总有效率依次为６８．０％，７０．０％和９０．９％（Ｐ均＜０．０１）。结论：联用天保宁与消心痛治疗冠心病心绞痛患者的心绞痛症状改善及心电图心肌缺血改善均明显优于单独用天保宁组或单独用消心痛组。

Objective:To investigate the therapeutic effect of taponin combined use of isosorbide dinitrate on angina pectoris.Methods:One hundred and fiftyfive cases of angina pectoris with coronary heart disease were divided randomly into 3 groups:50 cases were treated with taponin,2 tablets,3 times every day (group A);50 cases were treated with isosorbide dinitrate 10 mg,3 times every day (group B) and 55 cases were treated with taponin 2 tablets add to isosorbide dinitrate 10 mg,3 times every day (group C),3 weeks as 1 therapy course in 3 groups.Results:After 1 therapy course,the total effective rates of clinical symptom improvement were 720%,700% and 909% in group A,B and C,respectively (P<0025 and P<001).On the other hand,the total effective rates of electrocardiogram (ECG) changes were 680%,700% and 909% in group A,B and C,respectively (all P<001).Conclusions:The improvement of angina pectoris symptom,myocardial ischemia symptom and ECG abnormal in group of combine use of 2 drugs are superior to using single drug.