摘要
Liver samples from 42 patients with hepatocellular carcinoma(HCC) were examined for the presence of plus-strand and minus-strand HCV RNA by reverse transcription-polymerase chain reaction(RT-PCR). The results showed that the positive rates of plus-strand and minus-strand HCV RNA were 54. 8% and 35. 7% . respectively. In the patients,45. 2% was found positive for the plus strand and 31. 0% positive for the minus strand both in cancerous and non-cancerous liver tissues. Among those without detectable HCV RNA and anti-HCV,HCV RNA was detectable in liver tissues of 51. 3% of the patients. No correlation was found between HCV RNA and HBV markers in the liver tissues and the sera. The findings suggest that HCV infection in China may play another etiological role in the development of HCC,and the presence of HCV infection cannot be excluded for lack of antiHCC and HCV RNA in sera.
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