摘要
ＣｏｍｐａｒａｔｉｖｅｓｔｕｄｙｏｎｔｈｅｐｒｏｐｅｒｔｉｅｓｏｆＭＤＡ－ＬＤＬ＇ｓａｎｄｏ－ＬＤＬ＇ｓｒｅｃｅｐｔｏｒｓｏｎｍａｃｒｏｐｈａｇｅ￥ＤｉｎｇＺｈｅｎｈｕａ（丁振华）；ＣｈｅｎＹｕａｎ（陈瑗）；ＺｈｏｕＭｅｉ（周玫）；ＦａｎｇＹｕｎｚｈ...
By means of radioligand binding assay, both receptors of the malondialdehyde modified low density lipoprotein (MDA-LDL) and the oxidatively modified LDL(o-LDL) on the mouse's peritoneal macrophage (MPM) were studied. The results show that there were high affinity receptors for MDA-LDL and o-LDL on the MPM and both receptors had multiplicity of configuration based on the competitive-inhibition curve or parameters IC50 and Ki, and the acetylated LDL (Ac-LDL) and dextran sulfate can both competitively inhibit MDA-LDL or oLDL binding to these receptors in some degree.It is meanful to study the scavenger receptor multiplicity and its relationship to the genesis, protection and treamtent of atherosclerosis.
