摘要
Ｅｆｆｅｃｔｏｆｈｙｐｅｒｔｈｅｒｍｉａｉｎｃｏｍｂｉｎａｔｉｏｎｗｉｔｈｃｒｙｏｔｈｅｒａｐｙｏｎｓａｒｃｏｍａ１８０ｉｎｍｉｃｅ￥ＦａｎＪｉａｎｚｈｏｎｇ（范建中）；ＨｕａｎｇＺｈｕｏｙｕａｎ（黄卓垣）；ＣｈｅｎＰｉｎｇｙａｎ（陈平雁）；Ｓｏｎｇ...
The significant decrease in tumor recurrence caused by combined hyperthermia (local water bath) with cryotherapy has previously been shown. This study demonstrated an in vivo additive interaction of local microwave diathermy (hyperthermia, 42±0.5℃, 20 min. ) and liquid nitrogen treatment (cryotherapy,-180℃, 3 min. ) against intraperitoneally implanted sarcoma 180 in ICR mice. Local hyperthermia was produced by applicating 2450 MHz microwave to the region of the tumor without induction of significant whole body hyperthermia.Both hyperthermia and cryotherapy were delivered as a single dose individually on day 1 and day 2. The analysis of the tumor size curves showed that all of the treatments had more significant effect on sarcoma 180 than on the control group (P < 0. 0001 ). The optimal sequence of the combined therapies found in the experiment was cryotherapy→hyperthermia (CH) (P<0. 0001). Weights of the tumors excised from the mice on day 11 showed that the combined therapies (cryotherapy→hyperthermia or hyperthermia→cryotherapy) were more effective on sarcoma 180 than hyperthermia or cryotherapy used alone(P<0.01).
