测定血清LSA与TSA对恶性血液病诊断的价值比较

COMPARISON BETWEEN THE VALUES OFDETERMINING SERUM LSA AND TSA TO DIAGNOSEMALIGNANT BLOOD DISEASES

本组应用研究结果表明:恶性血液病患者血清LSA与TSA含量(175±61mg/L与1025±388mg/L,n=72)均显著高于良性血液病组(110±46mg/L与733±295mg/L,n=80)和对照组(93±19mg/L与639±178mg/L,n=205)(P<0.001)。测定血清LSA与TSA诊断恶性血液病的敏感度分别为87.5％与72.2％(P<0.05),特异度分别为72.5％与67.5％(P>0.1),准确度为81.6％与71.7％(P<0.05),诊断效率为63.4％与48.7％(P<0.01),证明LSA对恶性血液病诊断的价值优于TSA。该二法诊断恶性病的假阳性主要来自感染性疾病。血清LSA含量监测对患者疗效与病情监视、预后分析等具有显著意义。

The results of determining serum lipid - bond sialic acid (LSA) and total sialic acid (TSA) showed that the serum LSA and TSA of malignant blood diseases group (175±61mg/L and 1025±388mg/L, n=72) was significantly enhanced than both the benign blood diseases group (110±46mg/L and 733±295mg/L, n = 80) and the control group (93±19mg/L and 639±178mg/L, n = 205) (P<0. 001). To diagnose malignant blood diseases by determining serum LSA or TSA, their sensitivities were 87. 5% and 72. 2% (P<0. 05), specificities were 72. 5% and 67. 5% (P>0. 1), accuracies were 81. 6% and 71. 7% (P<0. 05) and diagnostic efficiencies were 63. 4% and 48. 7% (P<0. 01); the LSA was more valuable than the TSA. Both LSA and TSA had some pseudopositive cases in benign groups, which were mostly from infectious diseases. Kineticaly assaying serum LSA was very valuable in patient's condition and curative effect supervision or advance prediction.