CD40与ICAM-1在原发性肝细胞癌组织中的表达及临床意义

Expressions of CD40 and ICAM-1 in primary hepatocarcinoma and clinical significance

目的:探讨原发性肝细胞癌组织中CD40与胞间黏附分子1(ICAM-1)的表达与原发性肝细胞癌发生、发展的关系。方法:采用免疫组织化学S-P方法检测40例原发性肝细胞癌(简称肝癌)患者癌组织中CD40与ICAM-1的表达情况,并选择其中25例的癌旁正常肝组织(距癌组织≥2cm)作为对照。结果:40例肝癌患者癌组织中CD40与ICAM-1表达阳性率(47.5%和82.5%)均明显高于其癌旁正常肝组织(0.0%和8.0%)(P<0.01);CD40在肝癌中的阳性表达与肝癌淋巴结转移有关(P<0.05),与其分化程度无关(P>0.05);ICAM-1在肝癌中的阳性表达与肝癌淋巴结转移和分化程度均有关(P<0.05或P<0.01)。结论:CD40与ICAM-1在肝癌组织中均异常表达,可作为判断原发性肝细胞癌侵袭转移及预后的指标,并为原发性肝细胞癌的生物治疗提供实验依据。

Objective To investigate the expressions of CD40 and ICAM-1 in primary hepatocarcinoma and clinical significance and analyze their relationships with carcinogenesis and progression of liver cancer. Methods S-P immunohistoehemistry was used to detect the expressions of CD40 and ICAM-1 in 40 cases of hepatocarcinoma and 25 cases of normal liver tissue （distance from cancer tissues≥2 cm）. Results The positive expression rates of CD40 and ICAM-1 were 47.5% and 82.5% in liver cancer tissue, which was significantly higher than those in normal liver tissue （P〈0.01）. The positive expression rate of CD40 in liver cancer tissue was associated with lymph node metastasis （P〈0.05）, but not associated with histological grade （P〉0.05）. The positive expression rate of ICAM-1 was associated with lymph node metastasis as well as histological grade （P〈0.01 or P〈0.05）. Conclusion There are abnormal expressions of CD40 and ICAM-1 in liver cancer. It may be a reliable indicator to judge the invasion and metastasis and prognosis of primary hepatocarcinoma and provide experimental evidence for biological and clinical research.