Intralipid与Lipofudin在重症胰腺炎病人中的应用

Effect of fat emulsion on patients with acute nerotic pancreatitis

目的：研究两种碳链不同的脂肪乳剂对重症胰腺炎病人肠外营养支持效果，观察脂肪乳剂对胰腺炎病程、血浆游离脂肪酸的影响以及营养支持效果。方法：将３０例重症胰腺炎病人随机分为Ｉｎｔｒａｌｉｐｉｄ（Ｌ组）、Ｌｉｐｏｆｕｄｉｎ（Ｍ组）、无脂肪乳剂驵（Ｃ组）予以肠外营养（ＴＰＮ）支持，并测定电解质、血糖、转铁蛋白、前白蛋白、甘油三酯、胆固醇、血清游离脂肪酸、磷脂酶Ａ２、弹性蛋白、肝功能、Ｔ细胞亚群等指标，进行血气分析和计算氮平衡。结果：Ｃ组病人甘油三酯、亚油酸、亚麻酸呈下降趋势，Ｍ和Ｌ组前白蛋白值恢复正常，并接近正氮平衡。结论：重症胰腺炎病人应用脂肪乳剂对胰腺炎病程无不良影响，且能防止必需脂肪酸的缺乏。

Objectives:To study the effect of lipid on patients with severe pancreatitis. Methods:Thirty patients were randomly assigned to intralipid(L) group,Lipofudin(M) group and non fat(C) group.The TPN duration was 7 days.The following measurements were performed:free fat acid;triglyceride,chorestrol,albumin,prealbumin,transferrin,PLA 2,CD3 and CD4; etc. Results:There was no hypertirglyceridemid developed after fat emulsion was administered for 7 days.In C group nessary fatty acid and triglyceride was decreased;In M and L group,there was great increase of serum prealburmin and nitrogen blance. Conclusions:Intravenous fat emusion in patient with pancreatitis was safe and useful,which did not make pancreatitis deterioration.There was no difference between intralipid and Lipofudin in short term TPN.