摘要
精子活力及穿卵功能是比精子计数更有意义的检测指标。以这些检查为标准将以往棉酚给药量减少40%抗生育效果仍然可靠,同时还可避免低血钾等毒副反应的出现。减量60%抗生育效果不满意。
The main side effect of gossypol used as a male contraceptive is hypokalemia. In order to avoid this side effect, we further reduced the daily loading dosage from 20mg to 15mg and 10mg, and the maintenance dosage from 50 mg to 30 mg. 17 participants were divided into two groups.The first group of 6 participants took 15mg per day for 60 days for loading, and 30mg weekly for maintenance.The second group of 11 participants took 10mg per day for loading and 30mg for maintenance.In addition, two control groups with 8 and 10 participants each were included in this low dose study. One year study showed the antifertility efficacy of the 15mg program was as good as the previous regular dose(20mg) program,but that of the 10mg program was not as good, with one failure——pregnancy.One year follow-up of serum k in both 15mg and 10mg programs showed some decline in summer,but a similar decline was noted in the control groups. Hypokalemia was thought to be due to nephrotoxicity induced by gossypol, but in this study no significant change was demonsrtated with the very sensitive β_2-MG renal function test,So we believe that the change of serum K noted in this low dose study is probably due to weather but not gossypol.
出处
《中国男科学杂志》
CAS
CSCD
1990年第1期6-10,59,共6页
Chinese Journal of Andrology
关键词
棉酚
男用避孕药
低血钾
精子功能
gossypol
male contraceptive
hypokalemia
sperm function