鬼臼乙叉甙(VP-16)治疗急性白血病

Treatment of Etoposide (Vp-16) in Patients with Acute Leukemia

16例急性白血病患者接受鬼臼乙叉甙(VP-16)、阿糖胞苷(Ara-C)的治疗。10例为初治的M_4或M_5患者。5例有效,其中4例为CR,1例PR。另外6例是难治性白血病,包括1例慢粒急变,1例M_6(红-单细胞性),4例第一次或第二次复发者。他们之中仅三例获PR。鬼臼乙叉甙的副作用是骨髓抑制。

Sixteen patients with acute Ieukemia received etoposide (Vp-16) for 5 days, cytosine arabinosid (Ara-C) for 7 dayse. Ten patients were acute myelomonocyic or monocytic leukemia. Five of them responded, four attained complete remission and one a partial remission 6 cases of refractory leukemia, it included one patient with chronic myelocytic leukemia in blast crisis, one with AML-M6 (erythrobastic-monoblastic leukemia and four with acute leukemia relapsed first or second times. Only three of these achieved pratial remission. The side-effect of etoposide was myelosuppression.