藏族麻风患者头发及血清中十种元素的含量测定

Contents of 10 Kinds of Elements in Hair and Serium of Tibitan Leprosy Patients in Gansu Province

用原子吸收光谱法对甘肃甘南州藏族的麻风患者和健康者各50例头发及血清中钙、镁、铜、锌、铁、铬、镍、锶、锰和铅的含量做了测定,结果麻风患者头发中的钙、铜、锌、铁及锰均显著低于正常人(P<0.001),锶显著高于正常人(P<0.001),镁、铬、镍及铅差异无统计学意义(P>0.05);血清中的铜、锌、铁及锰显著低于正常人(P<0.001),铬(P<0.05)及镍(P<0.01)高于正常人,锶显著高于正常人(P<0.001),钙、镁和铅差异无统计学意义(P>0.05)。头发与血清之间这些元素的含量均呈显著的正相关关系。这些变化是发病的因素还是病理改变,尚待进一步探讨。作者认为以补充锌、铜、铁及锰制剂作为藏族麻风病人的辅助治疗值得研究。

The levels of calcium, magnesium,cop- per,zinc, iron, chromium, nickel, stron- tium, manganese and lead in the hair and blood of fifty cases of leprosy and of fifty healthy control have been determined with atomic absorption pho- tometer, and the results showed that the contents of calcium, copper, zinc, iron and manganese in hair of leprosy pa- tients all are significantly lower than in the controls (p<0.001) and strontium level is higher (p<0.001), but the le- vels of magnesium, chromium, nickel, and lead have no difference between them (p>0.05). The levels of copper, zinc,iron and manganese in the blood of leprosy patients are significantly lower than in controls (p<0.001 ) and chro- mium (p<0.05) strontium and nickel (p <0.01) are higher, but calcium, mag- nesium and lead show no difference be- tween them. The contents of these ele- ments reveal a positive correlation be- tween the hair and the blood. The au- thors consider that further investigation is needed to determine whether the changes of the contents of these elements in the hair of leprosy patients are pathogenetic factors in leprosy or re- sults of the disease. They suggest giv- ing Tibitan patients with leprosy some preparations of zinc, copper,iron and manganese as complementary treatment on a trial basis.