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脂联素与冠状动脉粥样硬化的研究进展 被引量：3

Advances in Research of Association Between Adiponectin and Coronary Atherosclerosis
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摘要 脂联素是由脂肪细胞特异性分泌的一种蛋白质,血浆中含量丰富,其浓度受肥胖、胰岛素抵抗、β肾上腺素能受体激动剂、腺苷酸环化酶激动剂、糖皮质激素影响。脂联素具有保持内皮功能稳态、抑制平滑肌细胞增殖及抗炎、抗动脉粥样硬化形成的特性,并与冠心病预后密切相关,脂联素受体激动剂及增敏剂将为冠心病的预防和治疗提供新的策略。 Adiponectin, a novel hormone made by fat tissue,is abundant in plasma. Plasma levels of adiponectin are associated with obesity,insulin resistance, β adrenergic receptor agonist, adenylate cyclase agonist, glucocorticoid. Adiponectin has properties of maintaining stable state of endothelium function and anti-atherogenic, anti-inflammatory and the ability to inhibit smooth muscle cell proliferation. The decreased plasma adiponectin levels might be associated with the extent of coronary artery disease and be as an independent predictor of patho-genesis and severity of coronary atherosclerosis. Adiponectin receptor agonist and sensitizer may serve as an important object for physiological and pathophysiological studies seeking potential therapeutic applications.
作者 王学英 郭丽君 高炜
机构地区 北京煤炭总医院心脏中心 北京大学第三医院心内科
出处 《心血管病学进展》 CAS 2009年第B04期1-3,共3页 Advances in Cardiovascular Diseases
关键词 脂联素 动脉粥样硬化 冠心病 adiponectin atherosclerosis coronary artery disease
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献21

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二级参考文献7

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共引文献6

同被引文献20

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引证文献3

二级引证文献4

心血管病学进展
2009年 第B04期

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