45例孕妇及其胎儿血清与胎儿组织维生素B_(12)浓度和储量的测定

SERUM AND TISSUE VITAMIN B_(12) CONCENTRATIONS AND RESERVES IN 45 FETUSES AND DETERMINATION OF SERUM B_(12) IN THEIR MOTHERS

本文测定了45例中、晚期孕妇和其胎儿血清B_(12)浓度以及胎儿肝、脾、肾、脑、心肌五种组织的B_(12)浓度和储量。妊晚期孕妇血清B_(12)浓度比妊中期明显降低,这是血液稀释、胎儿生长、激素作用和B_(12)结合蛋白的改变共同作用的结果。胎儿血清B_(12)浓度显著高于同期孕妇,说明孕母供给胎儿B_(12)是一个主动过程。胎儿肝脏B_(12)浓度和储量最高。大于28周组的胎儿各脏器B_(12)储量显著高于小于28周组,说明胎儿体内B_(12)的储存主要是在妊娠后期。

The serum vitamin B_(12) contents in 45 pregnant women in the second and third trimesters and their fetuses, and the B_(12) contents and reserves in the fetal liver, spleen, kidney, brain and heart muscle were determined. The serum B_(12) level in pregnant women in the third trimester was lower than that in the second trimester, which was the result of hemodilution, growth of the fetus, hormonal effects and changes in B_(12) binding proteins. The fetal serum B_(12) contents were significantly higher than the maternal, which demonstrated that there was an active transport of B_(12) from mother to fetus. The hepatic B_(12) level and reserve were the highest among the tissues analysed. Each tissue B_(12) reserve of the fetuses in the over-28-week group was significantly higher than that in the group under 28 weeks,which indicated that B_(12) in fetal body reserved mainly in the third trimester.