脂肪源性干细胞在缺血性心脏病中的研究进展

Study Development of Adipose Tissue-Derived Stem Cells in Ischemic Heart Disease

来自中胚层的脂肪组织与骨髓组织一样含有大量能自我更新和多向系分化潜能的细胞群称为脂肪源性干细胞。其取材方便、来源丰富,可在体外稳定增殖传代。研究发现它具有多向系分化潜能,可以分化为间充质来源的脂肪、骨、软骨、骨骼肌、神经、心肌等细胞,用以修复骨、软骨、心肌、骨骼肌、血管以及神经等组织。现主要介绍脂肪源性干细胞移植治疗缺血性心脏病的研究进展。

Adipose tissue originated from mesoderm, like bone marrow, contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages （termed adipose tissue-derived stem cells, ADSCs）. The cells possessing this activity can be obtained in large numbers from adipose tissue, and could stably proliferated and differentiated in vitro. The adipose tissue-derived stem cells can be differentiate adipogenesis,chondrogenesis,osteogenesis, myogenesis, neurogenesis of orgin ectoderm to restore functional capacity of damaged bone, cartilage, muscle, cardiovascular and nerve in vivo. The research work on the development of adipose tissue-derived stem cells in ischemic heart disease.