摘要
Hyperthermia (42-44℃) and photosensitizing therapy can destroy S180 tumor cells,reducemalignant ascites and prolong the survival times of mice with carcinomas.The highestcurative effect was observed when using a combination of the two treatments.Heating to44℃ has a greater destructive effect on tumor cells than has heating to 42℃.The resultsshow that this is due to a synergistic interaction between these two treatments.The fluores-cence spectrum of S180 cells was determined before and alter treatment,and the indicationwas that the synergistic effect is probably related to a new fluorescence product;the greaterthe intensity of the new fluorescence、the more marked the synergy of hyperthermia andphotosensitizing therapy.The maximum emission wavelength was 460nm (excitation wave-length 370nm).
Hyperthermia (42-44℃) and photosensitizing therapy can destroy S180 tumor cells,reduce malignant ascites and prolong the survival times of mice with carcinomas.The highest curative effect was observed when using a combination of the two treatments.Heating to 44℃ has a greater destructive effect on tumor cells than has heating to 42℃.The results show that this is due to a synergistic interaction between these two treatments.The fluores- cence spectrum of S180 cells was determined before and alter treatment,and the indication was that the synergistic effect is probably related to a new fluorescence product;the greater the intensity of the new fluorescence、the more marked the synergy of hyperthermia and photosensitizing therapy.The maximum emission wavelength was 460nm (excitation wave- length 370nm).
