甲基硝基亚硝基胍诱发小鼠膀胱肿瘤早期病变的动态观察

EARLY PATHOLOGICAL CHANGES IN BLADDER TUMOR OF MICE INDUCED BY N-METHYL-N-NITRO-N-NITROSOGUANIDINE

本项研究采取膀胱灌注 MNNG 诱发小鼠膀胱肿瘤,对 MNNG 引起膀胱上皮早期病变进行了动态观察。肿瘤的发生,发展经历了从单纯增生,乳头状,结节状增生,良性乳头状瘤,非浸润癌浸润癌这样一个典型的病理过程。诱发的膀胱肿瘤均为移行细胞肿瘤。

Experimental bladder tumors were induced in female mice by intravescical infus- ion of N-methyl-N-nitro-N-nitrosoguanidine.Early changes in the bladder epithelium of mice were studied.Our observations show that the lesions have a typical course of hyperplasia,noninvasive papilloma and invasive carcinoma and the tumors consist of transitical cells.