24小时动态观察纳多洛尔的降压疗效

A NONINVASIVE AMBULATORY 24-HOUR OBSERVATION OF THE CLINICAL EFFECT OF NADOLOL ON ESSENTIAL HYPERTENSION

作者通过24小时动态血压监测,观察纳多洛尔(萘羟心安)对高血压病患者的降压效果及两种不同剂量对血压和心率的影响。结果表明:纳多洛尔的降压疗效确切,增加剂量效果更加明显。并指出动态血压计具有重复性好,病人易接受,观察药物疗效更准确、更科学等优点。

Noninvasive ambulatory 24-hour blood pressure monitoring was used in a clinical trial of 41 cases with essential hypertension. The patients were randomly allocated to receive placebo (n=9), nadolol 40mg (n=18) and 80mg(n=14) once daily. The results of 24-hour blood pressure and heart rate recording after seven days of treatment were compared with those before treatment. Blood pressure was significantly reduced by 40mg of nadolol daily,while 80mg of nadolol per day resulted in blood pressure reduction to a greater extent. 24-bour blood pressure and heart rate recording showed a clear dose-response relationship for nadolol which could not be detected by ordinary casual readings. These results indicate that the tested noninvasive equipment is a useful tool for monitoring ambulatory 24hour blood pressure. It gives important information which is impossible to get from casual readings.