REBD—1稀土制剂对烫伤感染的疗效观察

The Therapeutic Effect of REBD-1(Preparation)on Burn Infection

采用大白鼠背部造成30%面积Ⅲ°烫伤为烧伤动物模型,伤后在创面涂布绿脓杆菌,并随机分为3组。第1组接受 REBD-1霜剂(稀土烧伤药1型)局部涂布治疗;第2组用 SD 银霜剂涂布治疗;第3组用制备 REBD-1霜剂的基质涂布创面作为对照组。从涂布药物的第二天开始,第1组和第2组的创面仅出现少量渗出物。创面较干燥,基本无溃烂,创面细菌培养比第3组的菌量减少2～3个数量级。在第3或第4周开始结痂,创面至7～8周已全部愈合。应用 SD 银治疗的创面因有银的沉着而变为黑色,故第1组实验动物的创面外观较清洁。第1组动物的死亡率为10%,而第2组无动物死亡。第3组基质对照动物,自涂布绿脓杆菌第2 天开始,创面呈现炎症并有渗出物或化脓形成,细菌培养有大量绿脓杆菌存在,动物死亡率为70%,感染后12～14天为死亡高峰。

30 scalded rats(Ⅲ burned with 30% TBSA),infected with p.pyocyaneus after injury,were divided at random into three groups thetherapeutic effect between REBD-1 and silver sulfadiazine on the burn infection with.p. pyocyaneus.Group 1 (N=10)received REBD-1 cream(preparation), group 2(N=10)silver sulfadizine cream,and group 3(N=10)only the substrate which was used to prepare the cream.The data,summerized in the table 1,showed that in both group 1 and group 2,only small amounts of exudate were abzerved begining from the 2^(nd) day after topical application of the drugs,and these appeared to be rather dry.Crust formation began on the 3^(rd) to 4^(th) week and the wound healed spontaneously in about 7～8 weeks after infection.The wounds of group 1 rats appeared generally cleaner than of group 2,because there was black deposition of silver in the tissue applied with silver sulfadiazine.The morality rate of group 1 was 10%,while no death was found in group 2.In contrast,the wounds in rats of group 3 were inflammed with exudate and pus formation,with high bacterial counts. The mortality rate was 70% with peak of death withoin 12～14 days after infection.