矽宁对大鼠实验性矽肺疗效及毒性研究

Hat Studies on the Curative Effect and Chronic Toxicity of Xinin on Experimental Silicosis in Rats

本文旨在探讨矽宁对大鼠实验性矽肺病后的疗效及毒性作用。实验分为三组,大(80mg/kg),小(40mg/kg)剂量组及矽肺对照组,每周给药3次,疗程6个月。实验结果表明:治疗组肺湿重,全肺胶原蛋白含量均明显低于矽肺对照组。治疗组矽结节病变主要由泡沫样细胞及纤维细胞构成,坏死细胞甚少。矽宁对实验性矽肺具有明显的抑制病变进展作用。主要受损的器官为心及肾,其毒性反应程度与药物的蓄积作用有关。

Toxicity and curative effect of Xining,an analogue of Tilorone,on ex-perimental silicosis of rats were studied.The silicotic rats were divided intothree groups:(1)Silicotic control group,(2)High dosage group(80mg/kg),and(3)Low dosage group(40mg/kg).Xining wasgiven orally to group 2 and 3 three times a week for six months.Results in-dicate that the silicotic lesions of the treated groups were much milder thanthose of the control group.The differences of collagen contents of wholelung and hilar lymph nodes between treated and control groups werestatistically significant.Silicotic Lesions in treated groups consist of Largefoam-like cells and fibroblasts aggregated in silicotic nodules.It may beconcluded that Xinin possesses significant inhibitive effect on the experi-mental silicosis of rats.Close relationship between the chronic toxic effectsand drug accumulation was shown.The main damages were found in theheart and kidney in high dosage group treated for six months.