慢性氯丁二烯中毒性肝病的临床研究

Clinical Studies on Chronic Chloroprene Toxic Hepatopathy

本文对41例慢性氯丁二烯中毒性肝病(CCTH)进行临床分析,并与慢性迁延型(CPH)、慢性活动型肝炎(CAH)及对照组比较,其结论如下:CCTH 的特点为有密切作业史;肝大伴质度改变,但肝功能多正常;常伴有明显的神衰、脱发及指甲变色;蛋白电泳可见白蛋白增高,β和α球蛋白明显减少;HBV 标志阴性;脱离作业后多可在1-3个月恢复。而CPH 及CAH多有严重的无力及消化道症状,常伴有黄痘及肝功能的异常;蛋白电泳可见白蛋白减少,γ球蛋白明显增高;HBV 标志多项阳性。如具备两种肝病的特征,并除外其它损肝因素的影响,可诊断为混合性肝病。

41 cases of chronic chloroprene toxic hepatopathy(CCTH)werestudied and compared with cases of chronic persistent hepatitis(CPS),chronic active hepatitis(CAH)and controls.Results of the studyshowed that all CCTH patients were closely related with their working his-tory.with liver enlargement and toughness on palpation,but their liverfunctions appeared to be normal.They often showed symtoms ofneurasthenia,alopecia and discoloration of nails.Protein electrophoresisshowed an increase of serum albumin and decrease of βand αglobulin.Their HBN being negative and most of them can recover 1-3 months afterleaving their working posts.CPH and CAH Patients often showed seriousasthenia with digestive disturbances complicated with jaundice and abnor-mal liver functions;decrease of albumin and increase of γ globulin can beseen by protein electrophoresis;HBV showed many positive signs.If thepatients have characteristics of both hepatopathy,excluding other factorsinfluencing their liver functions,it can be diagnosed to be a mixed typehepatopathy.