二巯基丁二酸驱铅效果的实验研究

Experimental study on efficacy of DMSA in lead removal

本文检测了二巯基丁二酸(DMSA)作为铅中毒拮抗剂的效果。测定小鼠急性腹腔注射醋酸铅的LD_(50)值为0.65mmolPb/kg,95%可信限为0.42～1.02mmolPb/kg。测定了DMSA拮抗铅中毒的致死效应和降低组织铅含量的能力,结果表明DMSA能够拮抗铅中毒的致死效应,增加小鼠的存活率。虽脾铅含量差异不明显,但DMSA处理小鼠的肝、肾、骨和脑铅含量均显著低于对照组。结果提示,DMSA是一种很有发展前途的络合剂,值得临床深入研究。

The ability of Meso-2, 3-dimercaptosuccinic acid(DMSA) to act as antagonist for lead poisoning has been examined in mice. The acute I. P. LD_(50) for lead acetate was found to be 0.65mmolPb/kg with a 95%0 confidence interval of 0.42 to 1.02mmolPb/kg. The ability of DMSA to offset the lethality of lead intoxication and the efficacy of DMSA to reduce tissue levels of lead were determined. The results showed that the DMSA was able to offset the lethality of lead intoxication and to increase the survival rate of mice. Although in mice treated with DMSA, the lead levels of the spleen were found to have little variation, yet that of the liver, kidney, bone and brain were lower than those of control groups significantly. The results indicated that the DMSA was a promising chelating agent and might need further clinical investigation.