未治白血病姐妹染色单体互换率和细胞周期时间的预后意义

Prognostic Significance of Sister Chromatid Exchange Frequency and Cell Cycle Time at Diagnosis in Untreated Leukemia Patients

本文报道了128例白血病姐妹染色单体互换(SCE)率和细胞周期(Tc)与生存期关系的回顾性研究结果,对生存期较长和生存期较短的两组病例SCE和Tc进行了比较。统计结果表明,除了慢性粒细胞白血病(CML)慢性期(CML-CP)Tc以外,大多数未治病例SCE频率显著异常(频率增高和降低)和/或显著延长的病例,其生存期较短,而SCE频率和/或Tc正常或轻度异常者,其生存期较长。因此,上述两个参数可作为白血病的早期预后指标.

This paper reported a retrospective study of the relationship between SCE frequency and TC values to survival time in 128 cases of leukemia. Statistical data indicated that survival time was generally shorter in patients with very high or very low SCE frequency and/or prominently prolonged TC. In patients with normal or milder changes of SCE frequency and/or Tc, the survival time was longer. Therefore, these two parameters may be regarded as a prognostic marker for leukemias.