磷酸咯萘啶不同制制与磺胺多辛、乙胺嘧啶伍用治疗恶性疟的效果

EFFICACY OF COMBINED USE OF VARIOUS PREPRATIONS OF PYRONARIDINE,SULFADOXINE AND PYRIMETHAMINE IN THE TREATMENT OF FALCIPARUM MALARIA

在海南岛抗药性恶性疟流行区,以磷酸咯萘啶(咯)片剂800mg、磺胺多辛(磺)1000mg、乙胺嘧啶(乙)50mg和咯针剂240mg、磺1000mg、乙50mg,2d疗法,分别治疗恶性疟39例与36例,两组平均退热时间分别为30.3±24.7和38.8±23.Oh;平均原虫无性体转阴时间为52.7±15.8和51.8±14.4h。随访28d治愈率均为100％。

Thirty-nine and 36 cases of falciparum malaria were treated by pyrona-ridine(PND, tablet)800mg/sulfadoxine(S)1000mg/pyrimethamine(P) 50mg and PND(injection) 240mg/S 1000mg/P 50mg in 2 days respectively in endemic area of chloroquine-resistant falciparum malaria in Hainan Island. The average fever subsidence time of the 2 groups were 30.3±24.7 h and 38.8±23.0h; the asexual parasite clearance time, 52.7±15.8 h and 51.8±14.4 h. No recurrence was observed during a 28-day follow-up.