不同剂量磷酸咯萘啶、磺胺多辛、伯喹伍用治疗抗氯喹恶性疟的观察

THE EFFECT OF COMBINATIONS OF PYRONARIDINE(PN),SULFADOXINE(S)AND PRIMAQUINE(PQ)ON CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

在云南西南部抗氯喹恶性疟流行区,用磷酸咯萘啶(咯)1000mg、磺胺多辛(磺)1000mg和伯喹(伯)45mg治疗恶性疟62例;咯1250mg、磺1250mg与伯56.25mg治疗20例;咯1200mg、磺1500mg与伯67.5mg治疗34例,进行比较观察,三组即时疗效相似,三组治疗后28d内的复燃率分别为15.5％、5.9％及8.7％;治疗后7d内的配子体清除率分别为66.7％、100％及100％,三组间有高度显著性差异。结果提示三药伍用治疗抗氯喹恶性疟时,咯萘啶总量不宜少于1200mg;伯喹不宜少于56.25mg。

One hundred and sixteen cases from endemic areas of chloroquine-resistant falciparum malaria in southwestern Yunnan, were respectively treated with three dose groups of combinations of PN/S/PQ, i.e. Group A 1000/1000/45mg, Group B 1250/1250/56.25mg and Group C1200/1500/67.5 mg, The recrudescence rates in Group A, B and C were 15.5%, 5.9% and 8.7%, the gametocyte clcarance rates 66.7%, 100% and 100%, with that in treaficantly differring from Band C(P<0.01). It suggests Group A signi tment of chloroquine-resistant falciparum malaria with PN/S/PQ combination, the dose of pyronaridine shouldn＇t be less than 1200mg and primaquine not less than 60mg to give radical treatment and interrupt its transmisson.