流行性出血热微血管的免疫病理改变

IMMUNOPATHOLOGICAL OBSERVATION OF MICRAGIOPATHIC CHANGE OF EHF

对42例流行性出血热患者的皮疹血管和13例患者的肝脾肺肾微血管做了免疫病理观察。HE染色表明上述微血管内皮细胞肿胀、退变、坏死,基底膜破坏,管腔狭窄或闭塞,微静脉比微动脉重。42例皮疹中26例(92.3％)兔抗人C_3-HRP-SPA染色示皮疹血管内皮细胞和基底膜呈阳性,对照组阴性。肺肾血管抗IgG、IgM,IgA荧光抗体染色阳性,说明微血管病变与免疫复合物沉积有关。39例患者循环免疫复合物升高。上述结果表明其病理变化属于Ⅲ型变态反应。

The erythra vessels of 42 casess with EHF and the micrangium of the liver, spleen,lung and kidney of 13 cases with EHF were observed. The HE staining shows that the endothelial cell of this micrangium is turgescent, degenerative and necrotic, the damaged basilar mambrane and stenosis or obstruction in the blood vessel. The changes in venule are more serious than artericle. 26 cases(92.3%) with erythra rabbit anti-person C_3-HRP-SPA staining show that the endothelial cell and basilar mambrane of erythra vessel are positive, but the control group is negative. The anti-IgG, anti-IgM, anti-IgA fluorescent antibody staining of the pulmonary and the renal vessels are positive. This observation shows that the pathologic change of micrangium is related to the immune complex deposit. The immune complex of circulation is increased in 39 patients. All of thie results show that the pathologic changes belong to type-Ⅲ allergic reaction.