小苏打对小鼠前胃鳞状上皮增生与癌变抑制作用的研究

RESEARCH OF INHIBITION OF SODIUM BICARBONATE TO HYPERPLASIA AND CANCERATION OF PROVENTRICULUS SQUAMOUS EPITHELIUM OF MOUSE

给小鼠灌注癌诱导物、食醋、小苏打,观察小苏打对小鼠前胃鳞状上皮增生和癌变的抑制作用。70天后,小苏打组无癌变发生,对照组为16.67％(5/30P<0.005);120天后,小苏打组癌变率为20％(6/30),对照组为59.3％(16/27 P<0.01)。结果表明,小苏打对小鼠前胃增生与癌变有明显抑制作用。

To fill the cancer inducer, vinegar and sodium bicarbonate to mice, the inhibition of sodium bicarbonate hyperplasia and canceration of proventriculus squamous epithelium was observed. After 70 days, the sodium bicarbonate group has no canceration, but the control group, shows 16.7%(5/30 P<0.005) for canceration. After 120 days, the canceration rate is 20%(6/30) and 59.3%(16/27 P<0.01) respectively. The results show that the sodium bicarbonate possesses the obvious inhibition to hyperplasia and canceration of proventriculus squamous epithelium of mice.