实验性肠梗阻时胆、胰、胃、肠功能的变化

THE CHANGES OF BILIARY, PANCREATIC ANDGASTROINTESTINAL FUNCTIONS DURING EXPERIMENTAL INTESTINAL OBSTRUCTION.

本工作从器官相关病理学的角度,观察实验性肠梗阻时消化器官的功能变化,藉以了解其变化规律及病理生理学意义。以 Wistar 大鼠为对象,用球囊扩张回肠上端,依加压程度和结扎局部血管制备低压、高压及高压缺血三种肠梗阻模型。结果显示:单纯肠内加压可引起胃酸分泌减少。三种肠梗阻时胆汁分泌均减少;胰液淀粉酶含量也减少,但胰液流量只在缺血组有显著降低。实验性肠梗阻后空肠对水与葡萄糖的吸收均有明显减少,而后者尤以缺血组更为显著。提示肠梗阻时消化液的分泌减少,可能是一种自稳机制的保护性反应,而小肠的吸收减少可能具有抗病与病损双重意义。

The purpose of present work was at the standpoint of organicinteraction pathology to observe the functional changes of digestiveorgans during experimental intestinal obstruction, through which todemonstrate the regularity and its pathophysiologic meaning. Theretypies of intestinal obstruction model were induced by distended theproximal jejunum with a balloon according severe or mild degree andwith local blood vessel ligation. It was showed that the gastric acidsecretion would be decreased at simple intestinal distention, and thedecreased degree were as same in ischemic and sham groups; the bilesecretion was decreased in all three typies of intestinal obstruction,among them the differences were not significant; and the content ofamylase in pancreatic juice was decreased in all three groups; but thesecretory volume of pancreatic juice reduced only in the ischemic one;the absorption of water and glucose in jejunum would be decreasedobviously after experimental intestinal obstruction, especially in theischemic group. It was suggested that the decrease of digestive juicesecretion during intestinal obstruction might be a protective response ofhomeostasis, while the decrease of intestinal absorption might be a doubleevent, which contained disorder and antidisorder in the pathophysiologicchange.