急性胰腺炎时肝功的变化及栀子的药效观察

EFFECT OF GARDENIA JASMINOIDES ELLIS ON THE CHANGES OF HEPATIC FUNCTION DURING ACUTE PANCREATITIS.

胰胆同病历来深受重视,但胰病时肝功的变化尚少了解。本实验以去氧胆酸钠诱发大鼠急性胰腺炎,就实验后1、4、6天时的血清淀粉酶、GPT、AKP、r-GT及胆固醇含量进行动态观察,并就栀子的影响进行对比研究。结果显示:大鼠胰腺炎后24小时血清淀粉酶明显升高,至第4天时即降至正常,栀子组的淀粉酶则稍有升高。胰腺炎后血清GPT、AKP及r-GT均有明显升高,而栀子组则AKP及r-GT,升高程度明显为低。至于GPT,服用栀子者虽在胰腺炎1天时也明显升高但第4天即降低至正常水平。术后6天时的胰肝组织学变化也显示服栀子者的炎症、出血等病变均较轻。表明急性胰腺炎可引起肝功发生一系列变化,而中药栀子则有促进机体恢复,减轻肝脏病变的药效。

The change of serum amylase, GPT, AKP, r-GT and cholesterol at the 1st, 4th and 6th day after experimental acute pancreatitis induced by DCA in SD rat, and the effect of Gardenia jasminoides Ellis on the biochemical changes was observed. It was demonstrated that the serum amylase raised obviously at the 24hr. after pancreatic duct injection with DCA, and it returned to normal at the 4th day, then lower than preoperation at the 6th day after injection. The serum amylase was also raised but lesser in the treated group, as compare to control thediffernce was not significant. The serum GPT, AKP arid r-GT were all raised obviously at the 1st day after pancreatitis induced, and they were lesser in the treated group. The serum GPT of treated animals returned to normal at the 4th day, while it was more and more raised in the control at the 4th and 6th day after operation. The histologic examine showed that there were serious inflammation, edema and hemorrhagic necrosis in pancreas and biliary ductal epidermal proliferation and cellular infiltration in the portal triad in liver slices. The mentioned changes were slightly mild and the general condition were obviously better in treated animals than the control.