PUVA治疗五年后银屑病患者的免疫功能状态

OBSERV ATION ON THE IMMUNOFUN CTION OF PSORIA SIS AFTER PUVA THERAPY FIVE YEARS LATTER

本文对50例PUVA治疗后5～8年的银屑病患者进行随访及免疫功能检查,结果和治疗前及治疗后近期比较,E-RFC、LTT都明显提高,而IgG、IgA、IgM均无明显差异。随访检查与正常对照相比较E-RFC、LTT、IgG、IGA均无明显差异,IgM恢复到银屑病治疗前水平。以上观察说明,PUVA治疗后5～8年中能使治疗后降低的细胞免疫功能及银屑病原紊乱的免疫功能得以恢复。随防中未见皮肤肿瘤、皮肤老化及白内障等并发症。

50 cases of psoriasis were trace after PUVA therapy 5-8 years latter. The values of different criteria of immunofunction were compared with that of pre and posttreatment. In cell mediated immunitas ERFC,LTT values increased predominantly, while that of IgG, IgM and IgA had no change. The values of ERFC,LTT, IgG, IgA and IgM inboth traced and control groups hadn't any difference. The level of IgM im traced group was significantly lower -ed than that of the control group, but restored to that of the patients before treatment. According to above observation, the cell mediated immunity lowered by PUVA theraps and original disturbed immunofunction could restore to normal rangey 5-8 years latter after PUVA therapy. During the course of examination in the traced patients, there were no skin cancer, aging skin and cataract observed.