病毒性肝炎与脂质过氧化作用的研究

A STUDY ON CORRELATION BETWEEN VIRAL HEPATITIS AND LIPID PEROXIDATION

本文研究110例病毒性肝炎患者血清丙二醛(MDA)及SGPT的关系,与30例正常人作对照。结果表明病毒性肝炎MDA含量X±SD为3.27±0.17(nmol/ml),其中急性黄疸型肝炎为3.29±0.24、急性无黄疸型肝炎为2.84±0.14,慢性活动性肝炎为3.35±0.15、慢性迁延性肝炎为2.87±0.19,MDA含量均较正常人(2.50±0.73)为高。各型肝炎患者的SGPT异常率为69.7％以上,其异常率的高低与MDA含量值的高低基本上是相关一致的,从而进一步验证了病毒性肝炎与脂质过氧化作用机理上的联系,这对病毒性肝炎的诊断及防治上有实用意义。

This paper studies the correlation between Malondialdehyde (MDA) and SGPT of 110 eases of Viral Hepatitis with 30 cases of healthy persons as con trol. The result shows that MDA concentration ((?)±nmol/ml) in serum of pat- ients, suffering from Viral Hepatitis, is 3.27±0.17, and that of acute icteric Hapatitis is 3.29±0.24, that of acute anicterie Hapatitis is 2.84±0.14, that of chronic active Hepatitis is 3.35±0.15, that of chronic persistent Hepatitis is 2.87 ±0.19. These figures indicate that MDA concentration of all these patients is higher than that of healthy persons (2.50±0.73). The abnormality rate of SGPT of the patients, suffering from Hepatitis of all types, is above 69.7%. The value of abnormality rate is coincident with that of the MDA concentration. The result shows that close correlation exists between Viral Hepatitis and lipid peroxidation mechanism. Data of this study are practically valuable for diag- nosis, treatment and prevention of viral Hepatitis.