慢性萎缩性胃炎胃泌素细胞的数量和形态学改变(免疫组化及超微结构研究)

The quantitive and morphologic changes of gastrin cells in chronic atrophic gastritis——An immunohistochemical and ultrastructual study

本文用免疫组化及透射电镜观察浅表性及慢性萎缩性胃炎的G细胞数量及形态变化。胃窦部粘膜68例,其中正常胃粘膜12例,浅表性胃炎6例,慢性萎缩性胃炎50例。浅表性胃炎及慢性萎缩性胃炎的G细胞数均比正常者减少,特别是后者。随着慢性萎缩性胃炎病变的加重,G细胞数也随之减少。慢性萎缩性胃炎G细胞分布不均,肠化区无G细胞,腺上皮不典型增生区G细胞明显减少。电镜观察详细地描述了正常胃粘膜和慢性萎缩性胃炎G细胞的形态。讨论了慢性萎缩性胃炎G细,胞数量减少和分布不均的原因,及其与胃癌的关系。

The article reports quantitive and morphologic changes of gastrin cells observed by immunohistochemistry and ultrastructure in superficial and chronic atrophic gastritis. The specimens obtained from the gastric antrum are cases:normal gastric mucose 12, superficial gastritis 6, chronic atrophic gastritis 50. The numbers of gastrin cells in superficial gastritis and in chronic atrophic gastritis are fewer than normal, especially in chronic atrophic gastritis. According as the gradation of the inflammatic changes becoming severer, the numbers of gastrin cells are fewer. The distributions of the gastrin cells are not even, in the intestinal metaplastic area the gastrin cell is absent, in the atypical glandular hyperplastic area, the gastrin cells are fewer markedly. The descriptions of the morphology of gastrin cells observed by ultrastructure in normal gastric mucose and in chronic atrophic gastritis is detailed. The causes of the number of the gastrin cells becoming fewer, the distribrtion unevenly, and The relationship between the gastrin cells fewer in number and malignant changes are discussed.